Abstract
The possibility of disturbances in Blood Sugar (BS) levels of Diabetes Mellitus (DM2) patients, following vaccination for Covid 19, is suggested, but not proved. No documented proof that vaccination actually disturbs the BS, is lacking. This article presents the first documented case of disturbed blood sugar, in a patient with DM2, on insulin, following vaccination for Covid 19 (Covishield).It is observed that initially there is increased Insulin Resistance, (IR) resulting in hyperglycaemia, which is temporary, self-limiting and doesn’t call for any increase in insulin dosage.This is followed by a more critical period, when there is increased insulin sensitivity, requiring decrease the pre- vaccination dose of insulin, as the risk of hypoglycemia is observed, as in the case under consideration. Hence, close monitoring and titration of revised insulin dosage, is called for, using a glucometer, during this second phase. Ultimately, the BS and insulin sensitivity/IR, return to the pre-vaccination levels. These disturbances may not come to light, unless the BS, following Covid 19 vaccination, is closely monitored. It is not predictable as to, in whom these disturbances in BS might occurs, and why it does so. The above inferences drawn are based on objective interpretation of the, truthfully recorded observations, during the case study period.
Highlights
It is not intended to review, in this article, the merits and demerits or safety profiles of the various vaccines available for Covid 19, as the same are reviewed extensively, elsewhere [1 -6]
Serum Institute of India (SII), has manufactured Covishield, the Indian variant of the AZD1222 vaccine developed by Oxford University and AstraZeneca .The other vaccine that has got emergency use authorization, Covaxin is, manufactured by Hyderabad-based Bharat Biotech in collaboration with the Indian Council of Medical Research (ICMR), New Delhi, India
Pre vaccination Pre vaccination Post vaccination. It is inferred from the data recorded in the tables, that initially there is increased insulin resistance /decreased insulin sensitivity, after the COVID-19 vaccination, followed by decreased insulin resistance/ increased insulin sensitivity, as compared with the pre-vaccination levels .The implication of the increased IR in the first phase, is that there is Hyperglycaemia .This is evident from the glucometer readings recorded in the tables 2 and 3)
Summary
University Campus, Rushikinda, Visakhapatnam, Andhra Pradesh, India. Publication history: Received on 25 May 2021; revised on 06 June 2021; accepted on 09 June 2021
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