Abstract

ABSTRACT Widely accepted public health actions and recommendations, particularly those related to vaccines, are critical to U.S. and global responses to infectious disease pandemics, such as COVID-19. For vaccination-related efforts like those involving COVID-19 vaccines, high national compliance is needed. While initial COVID-19 vaccination uptake in the U.S. has been quite high, it quickly became apparent that demographic characteristics, political ideology, and potentially news/information sources used were associated with COVID-19 vaccination acceptance, hesitancy, and resistance. Drawing from nationally published COVID-19 public opinion polls as well as social and behavioral science related to vaccination acceptance, this study used a nationally representative sample of U.S. adults 18 years-old and older, undertaken in November–December 2020, to examine how four key demographic characteristics (sex, age, race/ethnicity, education), political ideology (liberal, moderate, conservative), and news/information source preference (liberal, conservative, balanced) were related to COVID-19 vaccination intentions, COVID-19 risk-benefit perceptions, interest and attention to COVID-19 information, self-reported level of being informed on key COVID-19 items, and trust and use of common COVID-19 information sources. Multiple associations were found, with most having important implications for strategic communication efforts related to COVID-19 vaccination and other preventive health recommendations.

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