COVID‐19 presenting with autoimmune hemolytic anemia in the setting of underlying immune dysregulation

Abstract

To the Editor: The 2019 novel coronavirus (COVID-19 due to SARS-CoV-2 infection) pandemic has been declared an international public health emergency associated with substantial mortality with global case numbers surpassing 3 000 000.1 The clinical spectrum of COVID-19 disease in children and young adults ranges from asymptomatic infections to mild symptoms, only rarely leading to fulminant respiratory failure.2 Here, we report the first case of life-threatening immune cytopenias in a patient with SARS-CoV-2 infection. This case highlights a previously unreported potential COVID-19-related complication.2, 3 A17-year-old male with a history of refractory chronic immune thrombocytopenia (cITP) presented with progressive jaundice and fatigue in the setting of 4 days of emesis, diarrhea, and fevers. Prior to this presentation, the patient's cITP had been well controlled on eltrombopag and mycophenolate. Given the history of immune cytopenia, lymphopenia, splenomegaly, hypogammaglobulinemia, and a persistently elevated CD3+CD4-CD8-T-cell population in peripheral blood, the patient had been thought to have autoimmune lymphoproliferative syndrome (ALPS) or an alternative immune dysregulation syndrome. Clinical sequencing had been unrevealing to date for a known genetic cause of immune dysregulation.4 Importantly, the patient had previously negative direct antiglobulin (DAT) testing without signs of anemia or hemolysis, including in the months prior to presentation. Upon presentation, the patient was noted to be alert but fatigued. He was febrile, tachycardic, tachypneic, and hypoxic. His initial exam was notable for marked pallor and jaundice. He had clear breath sounds bilaterally, but increased work of breathing. Chest radiograph showed mild prominence of perihilar markings. PCR nasopharyngeal swab testing for SARS-CoV-2 was positive and negative for other respiratory viruses. Laboratory evaluation demonstrated warm DAT positive (IgG 3+, C3 1+) reticulocytopenic anemia with a hemoglobin of 2.5 g/dL and absolute reticulocyte count of 0.011 cells/μL, LDH of 1280 units/L, and total bilirubin of 8.9 mg/dL. Other abnormal hematological parameters included lymphopeniaand thrombocytopenia (Figure 1A). A peripheral blood smear demonstrated rouleaux formation, presence of microspherocytes, hypochromic microcytic red blood cells, and large platelets (Figure 1B). The patient was admitted and treated with intravenous corticosteroids and oxygen supplementation and received a red blood cell transfusion. Within 48 h after initiation of corticosteroids, hemolysis improved with a stabilized hemoglobin and significant decrease in bilirubin and LDH. Additionally, oxygen saturations normalized after red blood cell transfusion and his respiratory status improved. Given the patient's history of refractory cITP, he was restarted on his prior regimen of eltrombopag and mycophenolate and a steroid wean was initiated. Overall, this presentation was consistent with Evans syndrome with warm autoimmune hemolytic anemia (AIHA), a disease that can be triggered through polyclonal activation of autoreactive B-lymphocytes, leading to the emergence of red blood cell directed autoantibodies.5 While a direct causal relationship between SARS-CoV-2 infection and manifestation of AIHA cannot be demonstrated, the temporal association of this presentation suggests SARS-CoV-2 infection as a potential trigger, particularly in a patient with an underlying immune dysregulation syndrome. With the ongoing pandemic of COVID-19 disease attributable to SARS-CoV-2 infection, we suggest that patients who are immunosuppressed or have underlying immune dysregulation may have atypical presentations. Indeed, the notable immune activation with COVID-19 disease in adults3 may be associated with altered presentations in those with immune dysregulation, such as the development of new onset autoantibodies as we report here. National Institutes of Health; Grant Number: R01 DK103794.