COVID-19 Can Exacerbate Pattern Hair Loss and Trigger Telogen Effluvium - The Role of Proteoglycan Replacement Therapy with Nourkrin® in Clinical Treatment of COVID-19 Associated Hair Loss

Gadzhigoroeva Aida,Potekaev Nikolay N,Firooz Alireza,Espinoza Nelly,Simoes Marcela Mattos,Sanchez Daniela Guzman,Romanova Yulia,Suárez Hugo Vicente Martínez,Moravvej Hamideh

doi:10.23937/2469-5750/1510103

Abstract

The unfolding coronavirus disease 2019 (COVID-19) has increased the incidence of several dermatological disorders, including diffuse hair loss. Research revealed an escalated incidence of pattern hair loss (PHL) and telogen effluvium (TE) in COVID-19 patients. Psychological stress, systemic inflammation and oxidative stress are potential culprits. Reduced anagenic expression of proteoglycans is a potential mediating mechanism that connects hair loss to critical health conditions such as COVID-19. Proinflammatory cytokines and stress hormones negatively affect the normal metabolism of proteoglycans, which are known regulators of the hair growth cycle.

Highlights

Since late 2019, the global public health and wellbeing have been immensely challenged by the outbreak of a new strain of coronavirus designated ‘severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)’ [1]
We discuss the association between COVID-19 and diffuse hair loss and elucidate the position of proteoglycan replacement therapy (PRT) using Nourkrin® with Marilex® in addressing the dysmetabolism of proteoglycans in COVID-19
We propose that immune driven reactions are among the main etiological factors of COVID-19-related diffuse hair loss

Summary

Introduction

Since late 2019, the global public health and wellbeing have been immensely challenged by the outbreak of a new strain of coronavirus designated ‘severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)’ [1]. Reduced anagenic expression of proteoglycans is a potential mediating mechanism that connects hair loss to critical health conditions such as COVID-19. Proinflammatory cytokines and stress hormones negatively affect the normal metabolism of proteoglycans, which are known regulators of the hair growth cycle.

Results

Conclusion