Abstract
European Journal of ImmunologyVolume 48, Issue 2 Cover PictureFree Access Cover story: Eur. J. Immunol. 2'18 First published: 09 February 2018 https://doi.org/10.1002/eji.201870023AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Our cover features a packing diagram representing the structure of the Yellow Fever viral epitope HLA-A*02:01-LLWNPGMAV. Each asymmetric unit contains two copies of the HLA molecule (blue or yellow), with the peptide shown in stick model (green or brown). The image is taken from Bovay et al. (pp 258–272), who reveal that the immunodominant epitope of the Yellow Fever Virus is recognized by a highly biased T Cell Receptor (TCR) repertoire. A combination of X-ray crystallography and molecular modeling of the interactions between the TCR and the peptide-HLA-A2 complex provides new insight into the unusual high precursor frequency, prevalence and immunodominance of TRAV12-2 containing TCRs. Volume48, Issue2February 2018 RelatedInformation
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