Abstract
The cover picture shows a constrained peptidomimetic of the Asn-Pro-Asn-Ala-Asn motif that is found in the major surface protein of Plasmodium falciparum sporozoites. The mimetic (bottom) is coupled through a succinate linker to a regioisomer of phosphatidylethanolamine to afford a conjugate (top; the loop on the left represents the mimetic) that can be incorporated into immunopotentiating reconstituted influenza virosomes (IRIVs). When presented to the immune system in this form, the mimetic elicits an efficient parasite cross-reactive antibody response. The background shows immunofluorescence labeling of P. falciparum sporozoites (bright green rods). IRIVs are a form of antigen delivery that is already licensed for human clinical use so this approach may have great potential for the design and delivery of synthetic vaccines. For more details, see the article by Robinson, Pluschke, and co-workers on p. 838 ff.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
