Cover Picture: Bulk Electrocatalytic NADH Cofactor Regeneration with Bipolar Electrochemistry (Angew. Chem. Int. Ed. 3/2022)

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Bipolar electrochemistry , symbolized by the two electrodes at the opposite sides of the picture, can trigger the bioelectrocatalytic reduction of the important enzymatic cofactor NAD+, as reported by Lin Zhang, Alexander Kuhn et al. in their Communication (e202111804). The reaction occurs on the negatively polarized side—indicated by the δ− sign—of surface-modified catalytically active beads—illustrated by the planets—suspended in the bulk phase of an electrolyte. This wireless electrochemical approach allows a systematic tuning of the increase in conversion efficiency.