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Abstract

BiopolymersVolume 113, Issue 6 e23446 COVER IMAGEFree Access Cover Image First published: 23 June 2022 https://doi.org/10.1002/bip.23446AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Ropinirole hydrochloride (RH) is a promising anti-Parkinson's disease drug but suffers from low-clinical potency, often attributed to poor oral bioavailability, short plasma half-life and metabolism by the liver. Darwish et al. report the preparation of two nanoformulations to enhance delivery of RH to the brain: a self-assembled core-shell nanocapsule of RH and methoxy poly(ethylene glycol)-b-poly(caprolactone) coated with chitosan, and a RH-loaded chitosan-alginate polyelectrolyte nanocomplex. The mucoadhesive properties endowed by the chitosan and alginate promote RH delivery across the nasal mucosa and higher brain uptake of RH is seen in albino mice when the formulations are administered intranasally compared with intravenously. DOI: 10.1002/bip.23489 Volume113, Issue6June 2022e23446 RelatedInformation