Abstract

High-resolution light microscopy of Helicobacter pylori-infected gastric tissue (400× magnification): The picture shows a composite fluorescent image of gastric tissue stained with eosin (pseudo-colored blue) producing lactoferrin (pseudocolored overlay cyan), with the structure of lactoferrin in an inset (circular panel). H. pylori is a Gram-negative bacterial pathogen that infects the stomach and causes ulcers and gastric cancer. The host innate immune system produces the glycoprotein lactoferrin as part of the antimicrobial response to bacterial infection, and this molecule can repress the oncogenic activity of the H. pylori cag T4SS in an iron-dependent manner. More information can be found in the Full Paper by S. D. Townsend, J. A. Gaddy et al.

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