Cover Feature: Substituent Effects in Bioorthogonal Diels–Alder Reactions of 1,2,4,5‐Tetrazines (Chem. Eur. J. 29/2023)

Abstract

The fundamental mechanism driving the high reactivity of mono-substituted tetrazines is explored through substituent effects in the bioorthogonal Diels–Alder reactions of 1,2,4,5-tetrazines. Through computational analysis, the study unveils how an asynchronous approach of the reaction partner can mitigate adverse interactions during the reaction, leading to a reduction in the reaction barrier height. More information can be found in the Research Article by D. Svatunek and co-workers (DOI: 10.1002/chem.202300345).