Abstract
The Cover Feature shows cytochrome P450 3A4 revealing its magic ability to diversify natural products such as nootkatone to many functionalised metabolites in one step, as illustrated by a grey butterfly transforming into coloured butterflies. In their Research Article, N. D. Fessner et al. explored the synthetic potential of promiscuous human liver P450 3A4 for the late-stage diversification of natural products to produce oxyfunctionalised compound libraries of pharmaceutical or olfactory interest. The isolation of 31 authentic human metabolites at a 100 mg-scale from the P450 3A4-catalysed biotransformation of six selected terpenes, alkaloids and steroids represented an unprecedented degree of diversification. This study extends the synthetic repertoire for efficient enzymatic natural product modification. More information can be found in the Research Article by N. D. Fessner et al.
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