Abstract
Targeting of MCF-7 breast cancer cells was realized by conjugation of Gossypol to a tumor-homing cell-penetrating peptide. The peptide–drug conjugate was assembled through a tracelessly cleavable imine linker. This approach demonstrates the ease with which such peptides can be attached to Gossypol. Cleavage in aqueous media occurs over multiple hours, which makes this an interesting platform for peptide-guided delivery of an anticancer drug. More information can be found in the Communication by C. Hirshhäuser et al. on page 3010.
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