Abstract
The covalent structure of the major product of the interstrand cross-linking reaction of mechlorethamine [bis(2-chloroethyl)methylamine, nitrogen mustard] with duplex DNA was determined using synthetic oligodeoxyribonucleotide duplexes. Analysis of the mobility of cross-linked products by denaturing polyacrylamide gel electrophoresis (DPAGE) revealed the reaction to provide intrahelical, interstrand cross-links. These cross-links were cleaved on exposure to aqueous piperidine at deoxyguanosine residues, suggesting N 7 of deoxyguanosine residues as the site of alkylation on DNA
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