Abstract
The changes in depressive symptomatology during the first year following one-anastomosis gastric bypass (OAGB) were evaluated and its association with uric acid (sUA). Fifty patients were included in this analysis. Beck Depression Inventory (BDI) for measuring depressive symptomatology, blood samples, and anthropometric measurements were assessed before (T0), at 6 (T6), and 12 months (T12) after surgery. There was a significant reduction in BDI total score at T6 (− 5.6 (95% CI − 2.1, − 9.1) points; p = 0.001) and at T12 (− 4.3 (95% CI − 0.9, − 7.9) points; p = 0.011). BMI loss was unrelated to depressive symptomatology. Patients with moderate to severe depressive symptomatology presented lower sUA levels than patients with none or minimal to mild (p = 0.028). ROC analysis revealed that sUA levels below 5.0 at T6 and 4.5 mg/dl at T12 had a prognostic accuracy for depression severity. Furthermore, delta sUA was significantly associated with delta BMI (β = 0.473; p = 0.012) and delta waist circumference (β = 0.531; p = 0.003). These findings support an improvement in depressive symptomatology in the first year postoperatively, however, without relation to BMI loss. Patients with moderate to severe depressive symptomatology presented with lower sUA levels over time. Therefore, sUA could be useful to predict moderate to severe depressive symptomatology in patients undergoing OAGB in clinical practice.
Highlights
The changes in depressive symptomatology during the first year following one-anastomosis gastric bypass (OAGB) were evaluated and its association with uric acid
56% of the patients showed moderate to severe depressive symptomatology as measured by the Beck Depression Inventory (BDI)
receiver operator characteristic curves (ROC) analysis revealed that serum uric acid (sUA) levels had a moderate to good prognostic accuracy in the total sample
Summary
The changes in depressive symptomatology during the first year following one-anastomosis gastric bypass (OAGB) were evaluated and its association with uric acid (sUA). Delta sUA was significantly associated with delta BMI (β = 0.473; p = 0.012) and delta waist circumference (β = 0.531; p = 0.003) These findings support an improvement in depressive symptomatology in the first year postoperatively, without relation to BMI loss. Patients with moderate to severe depressive symptomatology presented with lower sUA levels over time. Utilizing data from the LOAD (“Link between Obesity And Vitamin D”) study, a six-months double-blind, placebo-controlled, randomized trial of vitamin D supplementation in OAGB patients, the aims of the current analysis are: (1) to describe changes in depressive symptomatology during the first year following surgery; (2) to examine whether depressive symptomatology changes in parallel with total body weight loss; (3) to determine the association between depressive symptomatology and sUA and (4) to examine whether decreases in sUA levels would correlate with weight change
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