Abstract
The purpose statement is to study the course of COVID-19 in patients with HIV infection and morphological changes in the lungs with their combined SARS-CoV-2 and secondary infections.Materials and methods: The study included 96 patients with HIV infection and SARS-CoV-2 infection confirmed by PCR, aged 26 to 54 years. The clinical manifestations, the content of CD4-lymphocytes and HIV RNA, the presence of secondary infections, and morphological changes in the lungs were studied.Results and discussion: In patients with HIV infection with moderate or severe immunodeficiency, a mild course of COVID19 (63.2%) was observed more often than in patients without immunodeficiency (14.3%). Four out of 9 patients with severe immunodeficiency developed a combined lesion of the lung tissue (SARS-CoV-2 + CMV and SARS-CoV-2 + Pneumocystis carinii) with a fatal outcome.Conclusion: In the diagnosis and treatment of COVID-19 in patients with HIV infection, it is necessary to take into account the severity of immunodeficiency and viral load.
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