Abstract
The oxyhaemoglobin dissociation curve (OHDC) and intraerythrocytic 2,3-diphosphoglycerate (2,3-DPG) play an important role in oxygen delivery, especially during shock. 62 determinations in eight septic shocks were carried out. Hem.O.Scan® drew the OHDC at standard temperature and P co 2; P 50 was modified for pH 7.40 (P 50 std) by algorithm. When the patients had recovered from the shock, their average P 50 std was higher than during the shock (p < 0.02), and much more so than in normal subjects (p < 0.01). There was a positive correlation between P 50 std and 2,3-DPG, arterial blood pH, haemoglobin and cardiac index, as well as between 2,3-DPG and arterial blood pH. On the other hand, there existed no correlation between P 50 std or 2,3-DPG, and Pa o 2, Pa co 2 and phosphoremia. The Hill number was normal.
Published Version
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