Abstract
A comprehensive model coupling the computational fluid dynamics with the population balance equation (CFD−PBE) for a continuous seeded mixed suspension mixed product removal (MSMPR)-helical tubular (HT) crystallizer assembly has been developed. The model accurately depicts the fluid dynamics, mass transfer, heat transfer and crystal size distribution (CSD) in the MSMPR-HT crystallizer. The crystallization system considered was to produce metastable α-form of L-glutamic acid. The PBE was discretized using a high-resolution central scheme and solved simultaneously with CFD equations in COMSOL Multiphysics® utilizing user-defined scalars. A good agreement was observed between the model and experimental data for the metastable α-form crystals of L-glutamic acid with uniform particles and a mean crystal size of 160 µm. The continuous crystallization under different stirrer speeds, saturated solution flow rates, inlet saturated solution concentrations and temperature was investigated. It was found the higher stirrer speeds, saturated solution flow rate and temperature lead to uniform distribution with smaller crystal size. Moreover, the mean crystal size becomes larger and the CSD wider when the saturated solution concentration increase.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
