Abstract
Coumarin possess a number of biological activities like anticoagulant, antimicrobial, anti-inflammatory, analgesic,antioxidant, anticancer, antiviral, antimalarial etc. Coumarin belongs to a group as benzopyrones, which consists of a benzene ring joined to a pyrone nucleus. In this work, new coumarin phtalonitriles derivatives were synthesized and characterized via spectroscopic techniques IR, 1H NMR, 13C NMR, mass spectra and elemental analysis.The synthesis of coumarin phtalonitriles resulting from a nucleophilic aromatic substitution reaction between 4-nitrophtalonitrile and coumarins derivatives. The complexing properties of the coumarin derivatives toward alkali metal, alkaline earth metal, some transition metals and some heavy metal cations have been investigated in acetonitrile by means of UV spectrophotometry absorption and conductivity methods. Thus, the stoichiometry of the complexes formed and their stability constants were determined
Highlights
Coumarins are an extremely important family of heterocyclic compounds owing to their presence in a large variety of biologically active substances and their use as valuable agents for pharmaceuticals and fine chemicals. [1,8] Over the past several decades, synthesis and screening of coumarin compounds for drug discovery has been a vital subject of constant interest in organic and medicinal chemistry. [9,11] The extraction and complexation properties of the synthesized coumarin phtalonitriles towards alkali and alkaline earth metal cations have been investigated in acetonitrile by means of UV s pectrophotometry and 1HNMR s pectros copy
The results s how the formation of ML and/or ML 2 species depending on the ligand and the cation. [12, 19] In this work, novel coumarin phtalonitriles derivatives have been synthesize d
Efforts to quantify the complexation equilibrium were based on the use of UV spectrophotometry, conductometric measurements were used to obtain preliminary estimates of the stoichiometry of complexes formed
Summary
Coumarins are an extremely important family of heterocyclic compounds owing to their presence in a large variety of biologically active substances and their use as valuable agents for pharmaceuticals and fine chemicals. [1,8] Over the past several decades, synthesis and screening of coumarin compounds for drug discovery has been a vital subject of constant interest in organic and medicinal chemistry. [9,11] The extraction and complexation properties of the synthesized coumarin phtalonitriles towards alkali and alkaline earth metal cations have been investigated in acetonitrile by means of UV s pectrophotometry and 1HNMR s pectros copy. Coumarins are an extremely important family of heterocyclic compounds owing to their presence in a large variety of biologically active substances and their use as valuable agents for pharmaceuticals and fine chemicals. [9,11] The extraction and complexation properties of the synthesized coumarin phtalonitriles towards alkali and alkaline earth metal cations have been investigated in acetonitrile by means of UV s pectrophotometry and 1HNMR s pectros copy. [12, 19] In this work, novel coumarin phtalonitriles derivatives have been synthesize d. Their complexation of alkali metal, alkaline earth metal and transition metal cations, and the liquid liquid extraction of metallic picrate salts by coumarin phtalonitrile derivatives 1-3 were investigated, . Efforts to quantify the complexation equilibrium were based on the use of UV spectrophotometry, conductometric measurements were used to obtain preliminary estimates of the stoichiometry of complexes formed
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