Abstract
A simple method is described for the determination of morphine in biological fluids (plasma and urine) by high-performance liquid chromatography with coulometric detection. The detector consists of three porous electrodes which are arranged in a way to give maximum selectivity and sensitivity. Quantiation of morphine is performed using naloxone as the internal standard. Sample preparation involves an extraction procedure from plasma and urine. The limit of qualification of the method is 1ng/mL plasma. The methodology was applied to measure blood levles in rats after subcutaneous administration of a slow-release morphine pellet.
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