Abstract
Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry relies upon linearity between the ion cyclotron excitation and the observed response. However, nonlinearities result from non-ideal applied electric and magnetic fields and Coulombic interactions. Here, we report nonlinear response at low excitation electric field magnitude due to Coulombic shielding. The measured ICR signal magnitude exhibits an excitation voltage threshold that increases monotonically with the number of shielding ions (i.e., unexcited ions). If shielding ions are not present, ICR signal magnitude versus excitation voltage is linear (e.g., for quadrupole-isolated ions of nearly a single m/ z). Finally, we show that shielding results in a reduced cyclotron radius at low excitation voltage, resulting in an increased rate of transient decay; thereby exacerbating response nonlinearity and excitation threshold for long data acquisition period.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
