Abstract
Abstract Background Sarcopenia is a syndrome that cause falls, fractures, and morbidity in geriatric patients. Early diagnosis of sarcopenia is important as it is known that muscle functions can improve with early intervention. We aimed to investigate whether urinary amino acid levels could serve as biomarkers of sarcopenia. Methods The study included ninety-one patients aged 45–65 who visited to our outpatient clinic. The patients underwent physical examinations, blood tests and sixteen distinct urinary amino acid levels were analyzed. Anthropometric measurements were performed. Physical performances were evaluated. Muscle strengths were measured. Muscle masses were analyzed. Patients were divided into 4 groups: pre-sarcopenic, sarcopenic, severe sarcopenic and non-sarcopenic. Statistical significance level was determined as p < 0.05. Results A total of ninety-one patients, 53 females and 38 males, were included in the study. Three patients had pre-sarcopenia, eleven had sarcopenia, and two met the criteria for severe sarcopenia, while seventy-five patients were non sarcopenic. A significant difference was found between the sarcopenia and non-sarcopenia groups in terms of glutamine and valine levels (p < 0.001 for both). In the ROC analysis, the cut-off value of glutamine and valine levels in detecting sarcopenia was determined as 492 µmol/L and 209 µmol/L (AUC: 0.875 and 0.968). Correlation analysis revealed a negative relationship between urinary leucine levels and both muscle strength and muscle mass Conclusions We found that patients with sarcopenia had high urinary glutamine and valine levels and that urinary leucine levels were associated with both muscle strength and muscle mass.
Published Version
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