Abstract
Extrinsic mechanical signals have been implicated as key regulators of Mesenchymal Stem Cell (MSC) differentiation [1]. It has been possible to test different hypotheses for mechano-regulated differentiation by attempting to simulate regenerative events such as bone fracture repair [2]. During such events, repeatable spatial and temporal patterns of tissue differentiation occur. More recently, in vitro studies have identified other environmental cues, such as substrate stiffness [3] and oxygen tension [4], as key regulators of MSC differentiation. The hypothesis of this study is that a computational model that assumes substrate stiffness and oxygen tension regulate stem cell differentiation can be used to predict the spatial and temporal patterns of tissue differentiation that occur during fracture healing.
Published Version
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