Abstract
To evaluate two various treatment strategies of bone metastasis including single fraction and multiple fraction radiotherapy A multistage Markov decision model was applied to assess the incremental costs per quality adjusted life year (QALY) gained of single fraction against with multiple fractions. Model cycles period was monthly in a 10 years time horizon with 1000 hypothetical cohort samples. EQ-5D questionnaire was used to estimate health realted quality of life(HRQol) in patients. To cope with parameters uncertainty we used a propabilistic sensitivity analysis by Monte Carlo simulation technique. Both cost and utilities variabls are discounted by 3% in base model The expected mean cost and quality adjusted life years were respectively $1360.77 and 40.41 months for patients receiving single fraction and $2656.95 and 47.60 months for multiple fractions arm. The incremental cost-utility ratio (ICUR) was $180.34 per QALY. Compared with one Iranian GDP per capita (6578 US Dollar) as recommended willingness-to-pay for one gained QALYs, the multiple fraction scenario was a cost effective strategy Policy makers should advocate the multiple fraction method instead of single fraction in treatment of patients with painful bone metastases.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call