Abstract
Three novel anti-angiogenic steroidal alkaloids, cortistatins J ( 1), K ( 2), L ( 3), have been isolated from the Indonesian marine sponge Corticium simplex. The chemical structures of cortistatins J ( 1), K ( 2), and L ( 3) were determined by 2D-NMR analysis to be unique abeo-9(10-19)-androstane-type steroidal alkaloids having isoquinoline unit instead of the side chain part, respectively. Cortistatin J ( 1) showed cytostatic anti-proliferative activity against human umbilical vein endothelial cells (HUVECs) at 8 nM, in which the selective index was 300–1000-fold in comparison with other cell lines.
Full Text
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call