Abstract
Light microscopic and ultrastructural changes in developing coronary collateral vessels were investigated after treatment with hydrocortisone (20 mg/kg/day orally) in the dog. The expected inflammatory reaction in the early stage of development (3 weeks) was absent, signs of injury to the vascular wall were lacking. At 3 and 8 weeks proliferation of rough and smooth endoplasmic reticulum and of the Golgi field was prominent indicating changes in the metabolism of the cells. The amount of extracellular MPS, collagen and new elastic material was decreased. Intimal hyperplasia occurred at the same rate in the treated as in the untreated animals. At 3 months the vascular architecture was restored, cellular hyperactivity had decreased.
Published Version
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