Abstract
Corticosteroids have a unique role in allergy therapeutics since they possess pharmacologic properties not shared by other commonly used agents. New studies indicate that glucocorticoids increase the synthesis of beta-adrenergic receptors in tissues, inhibit formation of leukotrienes, and prevent migration of inflammatory cells to the site of allergic injury. While it is not possible to dissociate anti-inflammatory activity from the tendency to cause adverse effects, the latter can be minimized by proper use of the drugs. In particular, alternate-day regimens with prednisone and the availability of a new generation of surface-active inhalation steroids have substantially reduced the prevalence of adverse effects associated with corticosteroid treatment of asthma.
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