Abstract
In 1956, Daughaday (1956 a) and Bush (1957) independently demonstrated by equilibrium dialysis techniques the presence in human plasma of a specific protein capable of binding corticosteroids with very high affinity but low capacity. These qualities clearly distinguished the interacting protein from albumin; it was termed the corticosteroid-binding globulin (CBG). At the same time, Sandberg, Slaunwhite and Antoniades (1957) reported steroid binding data obtained with human plasma and plasma protein fractions which could not be accounted for by albumin binding; they were interpreted Sandberg and Slaunwhite, 1958; Slaunwhite and Sandberg, 1959) as indicating the existence of a special protein of high binding affinity for corticosteroid hormones which was named transcortin. The background to this demonstration of transcortin has been recounted by Sandberg et al. (1966). Upton and Bondy (1958) confirmed in ultrafiltration studies the strong binding of small amounts of cortisol to a plasma protein other than albumin. Desgrez (1967) has summarized some of the observations that led to the recognition of CBG.
Published Version
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