Abstract
The effect of cortical spreading depression (CSD) on locomotor performance was studied during acquisition and retention of avoidance conditioning in the runway. During acquisition bilateral CSD selectively blocked start latencies, having no significant effect on running times. Where CSD did, on occasion, result in increased running times this was not attributable to a loss of postural reflexes or other motor impairment, but to the presence of competing responses such as freezing or retracing in the alley. It is suggested that CSD produces a learning deficit rather than any motor impairment.
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