Corrigendum

Abstract

Protein ScienceVolume 22, Issue 11 p. 1689-1689 CorrigendumFree Access Corrigendum First published: 21 October 2013 https://doi.org/10.1002/pro.2366 2339 AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat The authors of the article listed below1 have determined that, although the data presented in the paper noted below are correct, the interpretation of the data is incorrect based on new experiments; thus they publish this corrigendum. In a subsequent paper in Protein Science,2 the authors explain how the data in the previous “cellular disaggregase activity” paper were misinterpreted. Briefly, time-dependent amyloid fibril adsorption to the walls of multi-well plates or individual tubes was misinterpreted as fibril disaggregation. Methodology to quantitatively correct for this problem is presented in the subsequent paper. The authors apologize to the scientific community for their serious mistake of misinterpreting a decrease in thioflavin T fluorescence in the presence of biological extracts as Aβ1-40 amyloid fibril disaggregation. It is important to stress that the results in the subsequent article do not call into question the existence of a disaggregase activity in multi-cellular organisms. However, the thioflavin T-based Aβ1-40 amyloid fibril kinetic disaggregation assay carried out in standard plates at 37°C is invalid when used as evidence for a disaggregation activity. References 1 Murray AN, Solomon JP, Wang Y-J, Balch WE, Kelly JW (2010) Discovery and characterization of a mammalian amyloid disaggregation activity. Protein Sci 19: 836– 846. DOI: 10.1002/pro.363. 2 Murray AN, Palhano FL, Bieschke J, Kelly JW (2013) Surface adsorption considerations when working with amyloid fibrils in multi-well plates and Eppendorf tubes. Protein Sci 22: 1531– 1541. Volume22, Issue11November 2013Pages 1689-1689 ReferencesRelatedInformation