Abstract
Advanced Drug Delivery Reviews 61 (2009) 1386☆ This review is part of the Advanced Drug Delivery Reviews theme issue on “Matrices and Scaffolds for Drug Delivery in Tissue Engineering”.DOI of original article: 10.1016/j.addr.2007.03.018.⁎ Corresponding author.E-mail address: laura.suggs@mail.utexas.edu (L.J. Suggs).Fig. 3. (A) Schematic demonstrating a combination strategy for the delivery of HGF and BMNCs (bone marrow mononuclear cells) using a PEGylated fibrin biomatrix. Delivery wasevaluatedinamurineinfarctmodel.Cellretentionratewassignificantlyincreasedwhendeliveredbyinjectablebiomatrixcomparedwithdirectinjection.ThenucleioftransplantedBMNCs were stained blue by X-gal and the slides were counterstained by eosin (red). By direct injection only a few cells were detected at the periscar region. (Reprinted withpermission from Leni, A., Kajstura, J., and Anversa, P. (2005). Cardiac Stem Cells and Mechanisms of Myocardial Regeneration. Physiol Rev 85, 1373–1416.) (B) When delivered byinjectable biomatrix the transplanted BMNCs formed clusters at the peri-scar (C) area. The cell retention rates were compared between the two delivery methods. (D) (Reprintedwith permission from [106].)0169-409X/$ – see front matter © 2009 Elsevier B.V. All rights reserved.doi:10.1016/j.addr.2009.08.002
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