Abstract
Abstract Self-limited epilepsy with centrotemporal spikes (SeLECTS) is a common pediatric epilepsy, and this age-dependent subtype usually incidents in the golden period of brain development. The integration of multi-scale and cross-modal brain image data can help to analyze the neural mechanism of brain development. In this study, we aimed to test whether macroscale brain morphometric features were altered in children with SeLECTS, and how the differences were related to clinical phenotypes and brain metabolism profiles. We extracted five cortical morphometric features to construct morphometric similarity (MS) connectome. The study revealed significant case-control differences in the MS in children with SeLECTS, mainly involved in left prefrontal area, right precuneus, left supramarginal gyrus and medial temporal gyrus. The MS in supramarginal gyrus was negatively correlated with general intelligence measurements. And the global changes of the MS showed correlations between metabolism profiles of dopamine D2, glutamate and vesicular acetylcholine transporter distributions.
Published Version
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