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Abstract
Objectives:To study the correlations of circulating miR-26b level with left ventricular hypertrophy (LVH) and cardiac function in elderly patients with hypertension.Methods:A total of 132 eligible patients were divided into low and high miR-26b level groups. Their baseline clinical data and biochemical indices were compared. The correlations between miR-26b level and echocardiographic parameters were studied by Pearson’s analysis. Factors affecting LVH were explored by multivariate logistic regression analysis. The role of miR-26b in diagnosing LVH was predicted by receiver operating characteristic curve.Results:The relative expression level of miR-26b was 4.56-16.93, with a median of 7.62. The two groups had similar baseline clinical data and biochemical indices (P>0.05). Compared with high miR-26b level group, interventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT), left ventricular mass index (LVMI) and number of LVH cases in low miR-26b level group significantly increased (P<0.05), and mitral ratio of peak early to late diastolic filling velocity (E/A) decreased (P<0.05). Circulating miR-26b level was negatively correlated with IVST, LVPWT and LVMI (P<0.0001), and positively correlated with E/A (P<0.0001). The proportion of cardiac hypofunction cases in low miR-26b level group significantly exceeded that of high miR-26b level group (P<0.05). Age and increased IVST, LVPWT and LVMI were independent risk factors for LVH (P<0.05), and elevated miR-26b level was a protective factor (P<0.05). AUC was 0.836, and the optimal cutoff value was 8.83, with high sensitivity and specificity.Conclusions:MiR-26b level is negatively correlated with LVH and positively correlated with left ventricular diastolic function in elderly hypertensive patients. It is a protective factor for LVH complicated with diastolic dysfunction and a potential biomarker for diagnosis.
Highlights
As a common chronic disease bringing a serious economic burden, hypertension is mainly typified by the continuous rise of arterial blood pressure, and its long course changes the cardiac structure and function
The circulating miR-26b level was significantly negatively correlated with interventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT) and left ventricular mass index (LVMI)
The results showed that the relative expression level was between 4.56 and 16.93, and the median was 7.62 as the group cut-off value, and the value of
Summary
As a common chronic disease bringing a serious economic burden, hypertension is mainly typified by the continuous rise of arterial blood pressure, and its long course changes the cardiac structure and function. The early manifestations of hypertension include left ventricular hypertrophy (LVH) and diastolic dysfunction. Its pathophysiological mechanism has not been fully clarified, but miRNAs have been verified to participate in cardiovascular pathophysiological processes such as heart development and remodeling, arrhythmia and myocardial hypertrophy.[2] Circulating miRNAs, i.e. miRNAs in serum and plasma, can maintain extremely high stability under harsh conditions such as high temperature, acidity and alkalinity together with RNase.[3] The correlations of changes in the circulating miR-26 level with LVH and cardiac function in elderly patients with hypertension have seldom been referred hitherto. The circulating miR-26b level and echocardiographic parameters in these patients were detected to explore their correlations, thereby providing some guidance for the early detection and diagnosis of LVH upon hypertension
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