Abstract
Purpose: Synovial fluid biomarkers have great promise to distinguish between clinical OA stages and/or molecular endotypes of OA. There is an increasing understanding that both physiological and pathophysiological processes in the joint include aberrant cellular metabolism within myriad joint tissues. Metabolomics is a powerful platform for analyzing large numbers of metabolites within biological samples, and recent studies applying metabolomic profiling of synovial fluid have potential for developing biomarkers of osteoarthritis.
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