Correlations between daily weight gain, lipid peroxidation and glutathione status of liver and kidney in different pig genotypes

Miklós Mézes ,Mária Kovács-Weber ,Krisztián Balogh ,Györgyi Kollár ,Mónika Heincinger

doi:10.5194/aab-55-263-2012

Miklós Mézes , Mária Kovács-Weber + Show 3 more

Open Access

https://doi.org/10.5194/aab-55-263-2012

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Abstract

Abstract. Four pig hybrids (Pannon, Hungahib-39, Középtiszai and Dalland) were fattened up to 100±2 kg body weight. Feed intake and body weight were measured and daily weight gain was calculated. Malondialdehyde (MDA) and reduced glutathione (GSH) content, and glutathione peroxidase (GPx) activity were measured in liver and kidney. Daily weight gain was significantly lower in Pannon and Hungahib-39 hybrids. Amount of MDA was significantly higher in the liver of the hybrids with higher daily weight gain, and similar tendency was found in kidney. GSH content of liver did not differ significantly among the hybrids. The kidney of the Középtiszai hybrid had significantly lower GSH concentration than the others. GPx activity was the lowest in liver and kidney of Középtiszai hybrid. There was no significant correlation between daily weight gain and MDA content in liver, but positive correlation was found in the kidney of Pannon and Hungahib-39 hybrids. Daily weight gain showed significant correlation with GSH content of liver of Középtiszai hybrid. Between daily weight gain and GPx activity negative correlations were found in all hybrids and tissues, but none of them was significant. GSH content showed negative significant correlation with MDA content of liver of Középtiszai and in kidney of Pannon hybrid. Correlation between GSH content and GPx activity was positive and significant in the liver and kidney of Pannon hybrid. The results showed that different daily weight gain of pig hybrids has effect on the lipid peroxide and glutathione status of liver and kidney.

Highlights

Lipid peroxidation and cellular antioxidant defence, including reduced glutathione content and glutathione-peroxidase activity, have importance in the oxidative stability of pork (Krska et al 2001), because glutathione peroxidase reduces hydrogen peroxide and lipid hydroperoxides, potentially harmful pro-oxidants that may promote peroxidation of polyunsaturated phospholipids in biological membranes
The results of the present study showed that MDA content, as meta-stable end product, a marker of lipid peroxidation, in liver homogenate differed significantly among the hybrids
The higher growth rate possibly increases the formation of oxygen containing free radicals and lipid peroxidation, as it was described in pigs earlier (Brambilla et al 2001)

Summary

Introduction

Lipid peroxidation and cellular antioxidant defence, including reduced glutathione content and glutathione-peroxidase activity, have importance in the oxidative stability of pork (Krska et al 2001), because glutathione peroxidase reduces hydrogen peroxide and lipid hydroperoxides, potentially harmful pro-oxidants that may promote peroxidation of polyunsaturated phospholipids in biological membranes. Significant differences were found in some farm animal species such as poultry (Shaaban et al 2004); goose (Mézes et al 1989); rabbit (Virág et al 1996); sheep (Atroshi et al 1981); goat (Fidanci et al 2001); cattle (Wachter et al 1999) and pig (Lingaas et al 1991). There are some data about the correlation between glutathione peroxidase activity and some production traits such as weight gain in poultry (Shaaban et al 2004) and sheep (Atroshi et al 1981), carcass weight and percent of edible tissues in rabbit (Virág et al 1996). Adequate antioxidant defence can compensate the oxygen free radical-mediated damages and prevent from the development of degenerative pathological events (Brambilla & Cantafora 2004)

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