Correlation research on nasal administration of vitamin D3 and immunoglobulin E and immunoglobulin G4 in patients with allergic rhinitis

Abstract

Objective To discuss the correlation between nasal administration of vitamin D3 and immunoglobulin (Ig) G4 and IgE in patients with allergic rhinitis (AR) , and study the effect of vitamin D3 on the immune mechanism of AR. Methods Thirty patients with AR whose skin prick test (SPT) were positive were selected as observation group, and 30 patients with simple nasal septum deviation whose SPT were negative were selected as control group. All the patients were treated with vitamin D3 300 000 U nasal administration, once a week and 4 times in total. Seven days after treatment, the serum concentrations of IgE and IgG4 were measured by lightscattering and radioimmunoassay method. The changes were compared between before and after treatment. Results The serum concentrations of IgE and IgG4 in observation group before treatment were (280.91±43.47) and (0.57±0.12) g/L, and after treatment were (204.64±46.32) and (0.88±0.12) g/L, and there were statistical differences (P<0.05) . The serum concentrations of IgE and IgG4 in control group before treatment were (45.47±6.01) and (0.42±0.07) g/L, and after treatment were (43.40±5.74) and (0.50±0.07) g/L, and there were statistical differences (P<0.05). Conclusions Vitamin D3 could affect the concentration of IgE and IgG4 in patients with AR. Vitamin D3 may become a prevention and treatment method for the AR. Key words: Vitamin D; Rhinitis; Immunoglobulins