Vitamin D level and the correlation with IgE in children with allergic respiratory diseases

Abstract

Objective To explore the vitamin D(VitD) level and analyse the correlation with immunoglobulin E (IgE) concentration in children with allergic respiratory diseases. Methods Selected 70 children with allergic respiratory diseases, from 4 months to 14 years old.Used capture ELISA ALLERG-O-LIQ assay to detect the serum tIgE and Dermatophagoides pteronyssinus (Dp) sIgE.Used Elecsys to detect the VitD concentration.Data was processed by statistical software SPSS 19.0. Results The average concentration of VitD was (33.8±10.3) μg/L.There was no significant different of VitD concentration between sex.The distribution was varied in different allergic respiratory diseases.The level of VitD in children with asthma combined with rhinitis [(28.6±7.6) μg/L] was the lowest.The level of VitD in children with asthmatic bronchitis [(38.8±6.1) μg/L] was the highest.The level of VitD in children with asthma combined with rhinitis was lower than the children with asthmatic bronchitis, the level of VitD in children with allergic rhinitis was lower than the children with asthma, cough variant asthma and asthmatic bronchitis (P<0.05, respectively). Age, tIgE and Dp sIgE were negatively correlated with VitD (rs=-0.548, P=0.000; rs=-0.397, P=0.001; rs=-0.259, P=0.030). The age, tIgE and Dp sIgE level of VitD insufficent group were higher than the VitD sufficent group(P<0.05). Conclusions Serum VitD level could be associated with an increased risk of the development of allergic respiratory diseases.The children with allergic respiratory diseases should pay attention to the change of VitD level and supplement. Key words: Allergic respiratory diseases; Vitamin D; IgE; Correlation analysis