Correlation relationships of myocardial work indices with left ventricular ejection fraction and postsystolic strain index in healthy individuals

Abstract

Abstract Funding Acknowledgements Type of funding sources: None. Purpose to identify correlations between the indicators of the global work of the left ventricular (LV) myocardium with the ejection fraction (EF) and the post-systolic contraction index (iPSI) in healthy individuals. Methods the study included 70 healthy people: 34 men and 36 women aged 21 to 61 years (mean age 39.3 ± 8.9 years). Inclusion criteria: absence of complaints, anamnestic and physical data indicating the presence of cardiovascular diseases and / or damage to other organs and systems; ECG without significant changes; lack of regular intake of any medications. Exclusion criteria: diseases of the cardiovascular system, respiratory system, kidney, liver; type 1 and 2 diabetes mellitus; chest trauma; BMI> 30 kg / m2; poor visualization of the echogram. Echocardiography was performed on a Vivid GE 95 Healthcare scanner (USA). EchoPAC software version 202 (GE Healthcare) has been used. LVEF has been determined by the Simpson biplane method. The index of global myocardial work (GWI, mmHg%), global constructive work (GCW, mmHg%), global wasted work (GWW, mmHg%), global work efficiency have been assessed in automatic mode. (GWE,%). The iPSS and the number of segments, the PSS index of which was more than 1, have been automatically determined. Spearman"s correlation coefficient (r) has been used to study the relationship between quantitative traits. Results indicators of global myocardial work had the following values: GWE - 97.5 (97; 98)%; GWI - 2062.6 ± 345.5 mm Hg%; GCW - 2353.3 ± 344.6 mm Hg%; GWW - 45 (32; 68) mm Hg%. LVEF on average 60.8 ± 4.6%, iPSS - 1.35 (0.73; 2.35). The average number of segments with iPSS> 1 - 4 (3; 6) (26.5%). The correlation coefficient of LVEF with GCW was 0.49 (p = 0.00001), with GWI - 0.45 (p = 0.00007), with GWE - 0.25 (p = 0.032), with GWW - (-0 , 19) (p = 0.1). Correlation coefficient of iPSS with indicators of myocardial work: with GWE - (-0.85) (p = 0.0007), with GWW - 0.85 (p = 0.00004), with GCW - (-0.05) (p = 0.68), with GWI - 0.07 (p = 0.5). When determining the relationship between the number of segments with iPSS> 1 and GWE, the correlation coefficient was 0.46 (p = 0.0002), with GWW - 0.57 (p = 0.0003), with GWI - 0.26 (p = 0 , 03), with GCW - 0.12 (p = 0.3). Conclusions GCW and GWI had moderate positive correlations with LVEF. GWE and GWW had a strong relationship with iPSS and moderate correlations with the number of segments with iPSS> 1.