Correlation Pattern of oxLDL, cortisol, hsCRP, and Adiponectin Levels in Atherosclerosis Risk Population-Based on Framingham Risk Score

Kumboyono Kumboyono,Indah Nur Chomsy,Fitria Nugraha Aini,Titin Andri Wihastuti

doi:10.5530/pj.2022.14.3

Abstract

Background: The central pathology of cardiovascular disease (CVD) is atherosclerosis. Therefore, it is necessary to examine proteins involved in the and CVD disease mechanism to predict the occurrence of cardiovascular disease due to atherosclerosis. Purpose: This study analysed the correlation pattern of hsCRP, oxLDL, cortisol, and adiponectin levels in atherosclerotic risk population based on the Framingham Risk Score (FRS) to determine the risk of atherosclerosis. Methods Participants were selected using the purposive sampling method,158 participants classes were fired into three risk groups according to FRS. Blood samples were collected, a hsCRP, oxLDL, cortisol, and adiponectin levels were measured using Enzyme-linked Immunosorbent Assay (ELISA). Results and Discussion: Using the inner model test result, four significant direct relationships are formed, indicated by p-value< 0.000. It was FRS to oxLDL, cortisol adiponectin, cortisol to oxLDL, and oxLDL to adiponectin. Based on the indirect effect analysis, it is known that the indirect effect of FRS on Adiponectin through the increase in hs-CRP levels (0.211), FRS on Adiponectin increases in OxLDL levels is significant (-0.224). The coefficient of the effect of the FRS on Adiponectin levels through an increase in OxLDL levels is negative, and also FRS on Adiponectin. The indirect effect of FRS on Adiponectin is that the indirect effect and is not significant (4.083) through the increase in cortisol levels. Conclusion: All variables used in this study are correlated with each other. FRS with hsCRP and adiponectin form a relationship that directly affects each other. Meanwhile, FRS affect adiponectin through OxLDL and cortisol. Key words: Adiponectin, Atherosclerosis, Cardiovascular disease, Framingham Risk Factor, hsCRP.

Highlights

Cardiovascular disease is a severe global health problem and has become a significant cause of death in developed and developing countries
The indirect effect of Framingham Risk Score (FRS) on Adiponectin is that the indirect effect and is not significant (4.083) through the increase in cortisol levels
The indirect effect coefficient is 0.0211 and is not significant. This value means that HsCRP cannot mediate the relationship of FRS to Adiponectin

Summary

Introduction

Cardiovascular disease is a severe global health problem and has become a significant cause of death in developed and developing countries. The World Health Organization (WHO) states that around 17.9 million people died from cardiovascular disease in 2016, representing 31% of the total deaths worldwide. The primary pathology that causes cardiovascular disease is atherosclerosis.[3] Atherosclerosis is a chronic inflammatory disease characterised accumulation of cholesterol or plaque on the inner walls of arteries.[4] The process of atherosclerosis begins with the formation of fatty streaks, which are accumulations of foam cells in the intima layer of arteries. Atherosclerotic plaques will develop into increasingly progressive lesions due to the inflammatory process and cause various complications.[5,6,7]. The central pathology of cardiovascular disease (CVD) is atherosclerosis. Purpose: This study analysed the correlation pattern of hsCRP, oxLDL, cortisol, and adiponectin levels in atherosclerotic risk population based on the Framingham Risk Score (FRS) to determine the risk of atherosclerosis

Methods

Results

Conclusion