CORRELATION OF VITAMIN D WITH HOMEOSTASIS MODEL ASSESSMENTESTIMATED INSULIN RESISTANCE (HOMA-IR) IN POLYCYSTIC OVARY SYNDROME PATIENTS ATTENDING A TERTIARY CARE HOSPITAL

Abstract

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. Association of vitamin D {25(OH)D3} status with metabolic and hormonal dysfunction in PCOS has been investigated by some studies but the relationship between them still remains inconclusive. Therefore, this cross-sectional study aims to analyze the relationship between vitamin D level and HOMA IR (an indicator of insulin resistance) in women with PCOS. Aim And Objective: Aim: To investigate the association between vitamin D levels and PCOS in our population. To check whether serum vitamin D level has any impact Objective: on fasting blood sugar, fasting insulin and HOMA IR in a PCOS patient attending a tertiary care hospital in Kolkata. Materials And Methods: Our study was a Descriptive cross sectional study. The study included 146 PCOS patients in the age group 15-45 years attending the Gynaecology OPD of a tertiary care hospital (Calcutta National Medical College and Hospital) in Kolkata. 25(OH)D3 levels were measured by ELISA. Other biochemical parameters taken were fasting blood sugar (FBS), fasting serum insulin and HOMA-IR. The association between Vitamin D level and the above mentioned parameters was studied. Result:In our study vitamin D levels was negatively correlated with fasting blood sugar (FBS) levels (r=-0.879, p<0.001), fasting insulin levels (r=0.865, p<0.001) and and HOMA IR (r=-0.897, p<0.001). Conclusion: Our study showed that the serum 25(OH)D3 concentration was correlated with certain biochemical and endocrinal parameters like FBS, fasting insulin and HOMA IR, which are also considered as metabolic risk factors. So our study hints that vitamin D may have a decisive role in PCOS and has a potential to emerge as an associated biochemical parameter of PCOS. Multi-centre randomized controlled trials with large sample sizes are needed to explore the metabolic role of vitamin D supplementation in women with PCOS