Abstract
Background: Breast carcinoma is the most common malignant tumour and leading cause of cancer death among women worldwide. VEGF being a powerful mediator of angiogenesis, plays a major role in local growth as well as metastasis of many solid tumours including breast carcinoma.
 Objective: This study aimed to evaluate the significance of VEGF expression in breast cancer and its correlation with prognostic parameters. Materials and methods: This study was conducted over a period of one year (February 2015 to January 2016). VEGF expression was evaluated in 57 histologically diagnosed cases of breast carcinoma with known ER and HER-2/neu status.
 Result: Among 57 cases 52(91.2%) were positive for VEGF. Positive ER expression was seen in 39 cases which is 64.8% of total cases. 54% of the total cases were positive for HER-2/neu. VEGF expression was positively correlated (P value <0.05) with tumour grade, tumour size and negatively correlated with ER (p<0.005) and HER-2/neu (p<0.005). Significant correlation also found with tumour type (p<.005).
 Conclusion: Considering the observations of the current study, it can be concluded that VEGF may play a crucial role in the pathogenesis of breast carcinoma and has a positive correlation with biologically aggressive tumour. So consideration of this biomarker (VEGF) is to be regarded as a prognostic parameter and critical evaluator of targeted chemotherapy
 Bangladesh Journal of Medical Science Vol.18(3) 2019 p.513-518
Highlights
Breast cancer is the second most common cancer in the world and by far the most frequent cancer among women with an estimated 1.67 million new cancer cases diagnosed in 2012, according to globocan (WHO)
Strong VEGF was noted among the higher percentage (53%) of poorly differentiated breast carcinoma and it was positively correlated (Rho=0.290, p=0.02) .Tumour size(Chart: 3) was well correlated to immunoexpression of vascular endothelial growth factor with a P value of 0.004
Among 57 cases of breast carcinoma, 48 cases was invasive carcinoma of no special type (NOS) which accounted for 84.25% of total case and 18 among them had in situ component as well
Summary
Breast cancer is the second most common cancer in the world and by far the most frequent cancer among women with an estimated 1.67 million new cancer cases diagnosed in 2012, according to globocan (WHO). Among the many reported angiogenic factors, vascular endothelial growth factor (VEGF) is the most powerful endothelial cell specific mitogen that plays a key role in the complicated process of angiogenesis. VEGF being a powerful mediator of angiogenesis, plays a major role in local growth as well as metastasis of many solid tumours including breast carcinoma. Conclusion: Considering the observations of the current study, it can be concluded that VEGF may play a crucial role in the pathogenesis of breast carcinoma and has a positive correlation with biologically aggressive tumour. Consideration of this biomarker (VEGF) is to be regarded as a prognostic parameter and critical evaluator of targeted chemotherapy
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