Abstract
BACKGROUND: Breast carcinoma is the major cause of mortality and morbidity in Indian women. Though breast carcinoma arises from epithelial cells, stroma also plays a very important role in the pathogenesis of carcinoma breast which is assessed by the stromal marker CD 10. AIM : To study the stromal expression of CD 10 in carcinoma breast and find its relationship with other prognostic markers and study the role of stroma in pathogenesis of breast carcinoma. MATERIALS AND METHODS: 50 cases of breast cancer were included in the study. H & E slides were retrieved, reviewed and IHC was done with a panel of markers which included ER, PR, HER2/neu and CD 10. Stromal expression of CD 10 in invasive breast carcinoma was noted and analysed in correlation with other prognostic markers. RESULTS: Significances in the stromal CD 10 expression was calculated in regard to ER, PR & HER2/neu. Higher the tumour grade, more was the CD 10 stromal expression. CONCLUSION: As per the study, it is mandatory to include CD 10 stromal marker along with the panel of epithelial markers in invasive breast carcinoma. CD 10 contributes a potential target for development of novel therapies.
Highlights
Breast cancer is one of the leading causes of morbidity and mortality among women in the developing and developed countries
The aim of the present study is to evaluate the CD 10 stromal expression in breast carcinoma, to find its relationship with the other prognostic markers and study the role of stroma in breast cancer pathogenesis
Disappearance of CD 10 positive myoepithelial cells and basement membrane leads to the progression of DCIS to invasive carcinoma & CD10 expression of the stromal cells is correlated with poor prognosis, estrogen receptor negativity and high tumour grade.[3,4,12,13,14]
Summary
Breast cancer is one of the leading causes of morbidity and mortality among women in the developing and developed countries. Though breast carcinoma is an epithelial malignancy, stroma plays a key role in its development and pathogenesis. Along with the epithelial immunohistochemical markers, stromal markers are emerging as novel markers in assessing the prognosis of invasive breast cancer and is under trial. [2] Physiologically CD10 is expressed on the epithelial cells of breast. In infiltrating carcinoma of the breast, CD10 positivity of stromal cells increases and positivity in epithelial cells decreases. Breast carcinoma is the major cause of mortality and morbidity in Indian women. Though breast carcinoma arises from epithelial cells, stroma plays a very important role in the pathogenesis of carcinoma breast which is assessed by the stromal marker CD 10
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