Correlation of urinary albumin/creatinine ratio and blood pressure in young people

Abstract

Objective To explore the correlation of urinary albumin/creatinine ratio (urinary albumin-to-creatinine ratio, UACR)and blood pressure in young people. Methods Totally 200 cases of hypertensive patients (aged 18~50 years old) from January 2012 to March 2014 and 200 healthy volunteers who had medical examination in our hospital were selected with a random sampling method for staff questionnaires, biochemical tests, and physical examinations. Biochemical tests included kidney function, blood glucose, blood lipids, blood uric acid, and UACR. First, 400 cases were divided into four groups (1, 2, 3, and 4 groups) according to UACR quartiles from low to high. Second, 400 cases were divided into three groups according to their blood pressure: normal blood pressure, prehypertension, and hypertension. The correlation of UACR and different groups of blood pressure was analyzed. Results For norm blood pressure group, prehypertension, hypertension, the corresponding UACR level (median: 25%~75% quartile) was 0.8 (0.6~1.2) mg/mmol, 0.9 (0.7~1.4) mg/mmol, 1.0 (0.8~1.7) mg/mmol; positive UACR rate was 0, 2.6%, and 34.7%, three groups UACR levels and positive UACR rate index differences were statistically significant (P<0.05). After age factor was adjusted for 400 cases, both systolic and diastolic blood pressures were positively correlated with UACR levels. After body mass index, age, total cholesterol, and low-density lipoprotein cholesterol were adjusted for 400 cases, compared to group 1, the ratio of prehypertension to hypertension (95% confidence intervals) in groups 2, 3, and 4 was 0.98 (0.80~1.20), 1.29 (1.05~1.58), and 1.86 (1.52~2.28). Conclusions Urinary albumin/creatinine ratio was positively correlated with prehypertension and hypertension in young people. Key words: Albuminuria; Creatinine/UR; Blood pressure; Hypertension/UR