Correlation of soluble ST2 and pulmonary hypertension due to left heart failure

Sanlong Liu ,Yihua Liu ,Guangyi Huang ,Xiuhua Di ,Yu-Zeng Xue ,Jin-Jiao Shan ,Fei Xu ,Furong Chai

doi:10.3760/cma.j.issn.2096-3076.2019.02.007

Abstract

Objective To investigate the correlation between serum soluble ST2 (sST2) and pulmonary artery systolic pressure (PASP) estimated by echocardiography in patients with pulmonary hypertension (PH) due to left heart failure. Methods Patients hospitalized in Liaocheng People′s Hospital from October 2017 to March 2018 who were diagnosed with left heart failure with or without PH were enrolled and divided into those without PH (PASP≤35 mmHg) and those with PH (PASP>35 mmHg) according to the level of PAPS, the latter was further divided into mild PH group (PASP 36-50 mmHg) and moderate to severe PH group (PASP>50 mmHg). The relationship between PASP and sST2 was analyzed by using of Pearson correlation coefficient method and multiple linear regression and the predictive value of sST2 for PH was evaluated using logistic regression analysis. Results A total of 116 patients were enrolled and 90 were diagnosed with PH. The serum level of sST2 in patients with PH was significantly higher than that in patients without PH (P<0.01). Moreover, there was a significant higher level of sST2 in patients with moderate to severe PH group compared to that in patients with mild PH group (P<0.01). Serum levels of sST2 in both subgroups was significantly higher than that in patients without PH (both P<0.01). Correlation analysis showed that there was a significant correlation between sST2 and PASP (r=0.629, P<0.01). Multiple linear regression showed that serum sST2 was an independent predictor of PASP (P<0.01). Multivariate logistic regression analysis showed that serum sST2 was an independent predictor of PH [odds ratio (OR) 1.048, 95% confidence interval (CI) 1.015-1.082, P<0.01]. Conclusion Compared to those without PH, the serum level of sST2 was significantly higher in patients with PH due to left heart failure. Serum sST2 was significantly linearly correlated with PASP and an independent predictor of PH. Key words: Left heart failure; Hypertension, pulmonary; Soluble ST2

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