Correlation between pulmonary artery systolic pressure and ET-1 and VEGF in patients with congenital heart disease before and after transcatheter closure

Abstract

Objective To investigate the correlation between pulmonary artery systolic pressure and ET-1 and VEGF in patients with congenital heart disease before and after transcatheter closure. Method s 90 patients with right shunting CHD were divided into four groups according to the pulmonary artery systolic pressure (PASP): non pulmonary hypertension (PH) group (PASP <30 mmHg, 13 patients), mild PH group (30 mmHg ≤ PASP <50 mmHg, 24 patients), moderate PH group (50 mmHg ≤ PASP <70 mmHg, 31 patients), severe PH group (≥70 mmHg, 22 patients). The levels of ET-1 and VEGF were measured before operation, at one day after operation, one week after operation, and one month after operation, and the relationship between ET, VEGF, and PASP were analyzed. Result s Before operation, the levels of ET-1 and VEGF in mild PH group, moderate PH group, and severe PH group were significantly higher than those in non PH group (P<0.05), the levels of ET-1 and VEGF in moderate PH group and severe PH group were higher than those in mild PH group (P<0.05), the levels of ET-1 and VEGF in severe PH group were higher than those in moderate PH group (P<0.05). Linear correlation analysis showed that PASP was positively correlated with the level of plasma ET-1 before operation, at one day after operation, one week after operation, and one month after operation (r=0.713, 0.688, 0.686, 0.669, P<0.05), and serum VEGF (r=0.684, 0.700, 0.674, 0.645, P<0.05). There was a positive correlation between the level of ET-1 and VEGF in CHD patients before operation, at one day after operation, one week after operation, and one month after operation (r=0.525, 0.490, 0.491, 0.560, P<0.05). Conclusions Among CHD patients with left to right shunt, with the increase of pulmonary artery pressure, the levels of ET-1 and VEGF in the blood increase, which are positively correlated with PASP. After operation, we can evaluate the effect of transcatheter closure by detecting the levels of ET-1 and VEGF, and fully understand the roles of ET-1 and VEGF in the development of PH. The decrease of ET-1 and VEGF through intervention may be helpful to delay the progress of PH. Key words: Congenital heart disease; Pulmonary hypertension; Transcatheter closure; Endothelin-1; Vascular endothelial growth factor