Abstract
To evaluate serum uric acid level and correlate with the classification of chronic obstructive pulmonary disease (COPD) severity based on post-bronchodilator FEV1 as per Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines. It is an institution based cross-sectional study in which 100 patients were included. Patients were screened for COPD. Clinical profile and oxygen saturation were included. Patients were classified according to GOLD guidelines. We found that serum uric acid level was at higher side in patients of severe and very severe stages of COPD compared to mild and moderate stages. Inverse relationship found between FEV1 and serum uric acid level. We concluded that uric acid is a widely available, easy to interpret, low cost biomarker, suggests the possible role in the identification of COPD patients of increased risk for adverse outcomes that may need early intensive management. Keywords: Chronic obstructive pulmonary disease, GOLD guidelines, Spirometry, Serum uric acid.
Highlights
Pulmonary function declines with long term exposure to smoke.[1]
Tissue hypoxia induces the degradation of adenosine, which results in release of purine intermediates and end product of purine metabolism like uric acid.[2,3,4,5]
Distribution of patients according to spirometry classification of chronic obstructive pulmonary disease (COPD) depending upon post bronchodilator FEV1, were as follows, 7% patients were under the mild stage, 53% patients were under moderate stage. 27% patients were under severe stage, 13% patients were under very severe stage of COPD (Fig. 1)
Summary
Pulmonary function declines with long term exposure to smoke.[1] Impairment of pulmonary function results in decreased oxygen uptake, which results in tissue hypoxia in patients of COPD. Tissue hypoxia induces the degradation of adenosine, which results in release of purine intermediates and end product of purine metabolism like uric acid.[2,3,4,5] In this context, increased levels of uric acid are seen in respiratory disorders, including obstructive sleep apnoea[6] pulmonary thromboembolism.[7] There is data regarding the significance of serum uric acid level among patients with COPD.[8,9,10,11,12]. Serum uric acid has been proposed as a marker of impaired oxidative metabolism and an independent prognostic marker in several cardio-vascular disorders such as congestive heart failure[13,14] pulmonary hypertension[15] and myocardial infarction and its related complications.[16,17] There are other biomarkers which helps in assessing severity of COPD18-19 but they are not available and are costlier
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