Correlation of serum C - reactive protein with clinical parameters in diabetic patients having chronic periodontitis before and after treatment

Abstract

Background and Objectives: Chronic periodontitis is an infectious disease characterized by inflammation within the supporting tissues of the teeth, progressive attachment loss, and bone loss. C-reactive protein, are acute phase proteins monitored as a marker of inflammatory status. The present study was performed to determine whether presence of periodontitis and non-surgical periodontal therapy could influence the serum levels of CRP in type II diabetes mellitus disease patients. Materials and methods: A total of 60 subjects were selected for study. Venous blood samples were taken at base line and 3 months after non-surgical periodontal therapy for the type II diabetic patients with the clinical signs of chronic periodontitis (group I, n=30) and patients with chronic periodontitis having no diabetic mellitus (group II, n=30) to estimate serum C-reactive protein (CRP) level. Clinical parameters such as glycated hemoglobin (HBA1c ≥ 6.5% ), random blood sugar (RBS) and clinical periodontal parameters (Gingival Index, Probing pocket depth, Clinical attachment level and Plaque Index) for the group I and II were measured. Results: at base line, type II diabetes mellitus patients group I (T2DMCP) were compared to the non-diabetic patients with chronic periodontitis group II (NDMCP) based on the clinical periodontal parameters (GI,PPD, CAL and PI )scores and CRP level, HBA1c , (RBS) with the 3months after treatment. All the result was statically significant except for the GI and PPD scores at base line which was statically non-significant. The result also shows significant decrease in all the periodontal parameters and CRP level at base line as compared to 3months after treatment when group I was compared to group II while there was no significant change in the CRP level in group I and HBA1c in group II at base line as compared to 3months treatment. Conclusion: The present study concludes that total CRP level were decreased after non-surgical periodontal therapy.