Abstract
ABSTRACT: Bone trauma triggers an acute inflammatory response, which can alter the serum concentration of acute-phase proteins (PFA). We aimed to evaluate the effectiveness of PFA measurement as a laboratory biomarker for inflammation related to bone regeneration. A partial ostectomy of the right radius was performed on 22 young male rabbits. The complete blood count, albumin, ceruloplasmin, haptoglobin, C-reactive protein, and transferrin levels were recorded and correlated with the radiographic evolution of bone healing. Statistically the best correlations with the inflammatory process and radiological findings were reported with haptoglobin and transferrin compared to the other measured PFAs. Haptoglobin and transferrin showed a maximum peak 24 and 36 hours after surgery, respectively. Transferrin displayed signs of decrease in the first 6 hours after surgery, in advance of the leukocyte response. The measurement of acute-phase proteins proved to be viable, considering the conditions in which the present study was carried out. Among all variables studied, haptoglobin and transferrin showed best correlation with the inflammatory process of bone healing. Additional studies are needed to determine the sensitivity of acute-phase proteins as predictors of complications in the treatment of fractures.
Highlights
Physical injury and bone regeneration have been widely studied so as to improve the treatment of fractures and other bone disorders (MARSELL & EINHORN, 2011)
Despite the established need to investigate implants and new techniques to improve bone healing capacity, researchers around the world have been looking for ways to standardize markers capable of predicting complications in the treatment of orthopedic conditions
A complete blood count is considered to be the reference standard for postoperative follow-up, there is a need for biomarkers that can anticipate the development of complications, allowing for earlier intervention and better results (GOVAERT et al, 2020)
Summary
Physical injury and bone regeneration have been widely studied so as to improve the treatment of fractures and other bone disorders (MARSELL & EINHORN, 2011). Despite the established need to investigate implants and new techniques to improve bone healing capacity, researchers around the world have been looking for ways to standardize markers capable of predicting complications in the treatment of orthopedic conditions. In most cases, the process is already established. A complete blood count is considered to be the reference standard for postoperative follow-up, there is a need for biomarkers that can anticipate the development of complications, allowing for earlier intervention and better results (GOVAERT et al, 2020). Bone repair involves an inflammatory process with the intense action of pro-inflammatory cytokines, growth factors, and angiogenic factors
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