Correlation of prognosis with changes of serum cholinesterase, procalcitonin and d-dimer in patients with severe pneumonia

Abstract

Objective To invesitage the correlation of the change of serum cholinesterase, procalcitonin and d-dimer with the severity and prognosis of patients with severe pneumonia. Methods A total of 284 patients with community acquired pneumonia who were in accordance with the inclusion criteria were selected. Among them, 110 patients with severe pneumonia were hospitalized in ICU and 90 patients with community acquired pneumonia were hospitalized in the common respiratory department. According to the outcomes, patients with severe pneumonia were divided into improved group and deteriorated group. The levels of the serum cholinesterase, procalcitonin and d-dimer in each group and the relations with APACHE Ⅱ score were detected. Results As compared with the common pneumonia, the level of serum cholinesterase of the severe pneumonia patients significantly reduced, there was significant difference(P<0.05). However, the levels of procalcitonin and d-dimer were remarkably elevated(P<0.05). As compared with the improved group, the level of the serum cholinesterase of deteriorated group was significantly reduced(P<0.05). However the levels of procalctionin and d-dimer were significantly increased(P<0.05). Pearson linear correlation analysis indicated the level of serum cholinesterase of the severe pneumonia patinents was negatively correlated with the APACHE Ⅱ score(r=-0.575, P<0.05). However, the levels of procalctionin and d-dimer were positively correlated with the APACHE Ⅱ score(r=0.640, r=0.363, P<0.05). Conclusions The levels of serum cholinesterase, procalcitonin and d-dimer can reflect the severity and prognosis of patients with severe pneumonia. Key words: Severe pneumonia; Cholinesterase; Procalcitonin; D-dimer; APACHE Ⅱ score