Serum prealbumin and cholinesterase in patients with acute leukemia and its clinical significance

Abstract

Objective To investigate the changes and clinical significance of serum prealbumin (PA) and cholinesterase (ChE) levels in acute leukemia(AL). Methods From January 2014 to March 2016, a total of 40 newly diagnosed AL patients hospitalized in Xinghua People′s Hospital of Jiangsu Province were enrolled in the newly diagnosed group (n=40). Meanwhile 26 AL patients who underwent complete remission (CR) by formal chemotherapy were enrolled in the remission group (n=26) and 40 healthy individuals who underwent physical examination at the same hospital were randomly selected as the control group (n=40). There was no significant difference in the general clinical data among three groups (P>0.05). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Xinghua People′s Hospital of Jiangsu Province and informed consent was obtained from each participants. Serum PA and ChE levels were measured in subjects among three groups. One-way analysis of variance (ANOVA) was performed among three groups, and the least significant difference (LSD) was used for pairwise comparison. Serum PA and ChE levels correlation analysis using scatter plot and Pearson linear correlation analysis. Results The serum PA levels of newly diagnosed group, remission group and control group were (166.22±71.74)mg/L, (284.20±70.58)mg/L and(296.11±53.65)mg/L, respectively.And their serum ChE levels were (4 560.43±1 683.29)U/L, (6 689.08±1 629.91)U/L and (7 506.13±1 627.80)U/L, respectively. There were significant differences in serum PA and ChE levels among three groups (F=42.016, 31.289; P<0.05). The serum PA and ChE levels in newly diagnosed group were obviously lower than those of control group and remission group, respectively, and the differences were significant (P=0.000, 0.000, 0.000, 0.000). There was no significant difference in serum PA and ChE levels between remission group and control group (P=0.609, 0.076). The scattergrams showed that all the scatter plots of serum PA and ChE levels in newly diagnosed group, remission group and control group had linear trend.Results of Pearson linear correlation analysis showed that there was a positive correlation between serum PA and ChE levels in all three groups (r=0.589, 0.420, 0.663; P<0.05). Conclusion Serum PA and ChE levels may serve as serum biomarkers for the diagnosis and assessment of AL patients. Key words: Leukemia; Prealbumin; Cholinesterases