Abstract
Investigation of a potential prognostic marker expressed in non-small cell lung cancer (NSCLC) can help patients benefit from new target therapeuticmodalities. To study the expression and correlation of P53 protein and epithelial-mesenchymal transition (EMT) related makers in NSCLC. 32 cases were selected for immunohistochemistry analysis to evaluate the expression of P53 and EMT-related makers. The positive expression rate of P53 and the incidence of EMT in NSCLC were closely linked to TNM stages, differentiation degree, and lymph node metastasis (P < 0.05). A positive association was found between P53 and EMT (r = 0.380, P < 0.05). There is a positive association between P53, snail, and EMT. P53 may affect EMT in NSCLC by up-regulating the expression of Snail and further promoting cancer invasion and metastasis.
Published Version
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